Celox is made of chitosan, a compound derived from shrimp shells. Chitosan has proven antimicrobial properties and is not a procoagulant. Chitosan is broken down and absorbed through normal metabolic pathways and has an extensive history of use in vascular closure and in human cardiac surgery. Celox has a three year history of use in emergency, military, and retail first aid with no reported incidents. It has none of the risks associated with pro-coagulants and nano-particulates. An external review was commissioned on the safety of Celox’s ingredients in the body and concluded that Celox was safe to use internally in surgery and that residual quantities presented no risk. Shellfish allergies are not an issue.